APIDRA PACKAGE INSERT PDF

Apidra SoloStar Units/ml solution for injection in a pre-filled pen – Patient The Patient Information Leaflet (PIL) is the leaflet included in the pack with a. Apidra SoloStar Units/ml solution for injection in a pre-filled pen . SoloStar, the Instructions for use included in the Package leaflet must be read carefully. APIDRA [insulin glulisine injection (rDNA origin)] is a recombinant . package insert, and the pump manufacturer’s manual (see DOSAGE AND.

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The hyperglycemic effect of diazoxide is expected to be antagonized by certain antidiabetic agents e. Change the needle and try again. In large aidra, salicylates uncouple oxidative phosphorylation, deplete hepatic and muscle glycogen, and cause hyperglycemia and glycosuria. If you are not able to swallow or if you are unconscious, you will require an injection of glucose or glucagon a medicine which increases blood sugar.

Coma, diabetic ketoacidosis, hyperosmolar hyperglycemic state HHS.

Fast-Acting, Mealtime Insulin | Apidra® (insulin glulisine [rDNA origin] injection)

Careful monitoring of blood glucose is recommended. Before removing the needle from the vial, check your syringe for air bubbles.

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. Possible mechanisms include atypical antipsychotic-induced insulin resistance or direct beta-cell inhibition. Insulin glulisine is administered by intermittent subcutaneous injection and can be used for administration via external SC insulin infusion pumps. Never use SoloStar if it is damaged or if you are not sure that it is working properly.

Turn the vial of insulin glulisine and syringe upside down. Making sure the tip of the needle is in the insulin, pull back on the plunger to fill the syringe with the prescribed number of units of insulin. For information on the treatment of hypoglycaemia, see box at the end of this leaflet. Always perform the safety test before each injection see Step 3.

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Limited data are available regarding the pharmacokinetics of intravenously administered insulin glulisine. Adjust treatment with antidiabetic agents as clinically indicated. A common regimen is to administer insulin glulisine just prior to the beginning of each meal with a basal insulin i.

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Indapamide can decrease insulin sensitivity thereby leading to glucose intolerance and hyperglycemia. If you use more Apidra than you should If you have injected too much Apidra, your blood sugar level may become too low hypoglycaemia.

Insulin glulisine can also be administered intravenously with medical supervision in a clinical setting for glycemic control. Monitor for loss of glycemic control when pseudoephedrine, phenylephrine, and other sympathomimetics are administered to patients taking antidiabetic agents. Remove the needle from the skin and press gently on the injection site for a moment but do not rub or massage.

Ethanol inhibits gluconeogenesis, which can contribute to or increase the risk for hypoglycemia. Minor Diazoxide, when administered intravenously or orally, produces a prompt dose-related increase in blood glucose level, due primarily to an inhibition of insulin release from the pancreas, and also to an extrapancreatic effect.

While beta-blockers may have negative effects on glycemic control, they reduce the risk of cardiovascular disease and stroke in patients with diabetes and their use should not be avoided in patients with compelling indications for beta-blocker therapy when no other contraindications are present. Minor Fosphenytoin and other hydantoins have the potential to increase blood glucose and thus interact with antidiabetic agents pharmacodynamically.

If you turn past your dose, you can turn back down. Warning symptoms of hyperglycaemia Thirst, increased need to urinate, tiredness, dry skin, reddening of the face, loss of appetite, low blood pressure, fast heart beat and glucose and ketone bodies in urine. Be familiar with your warning symptoms. Patients with xpidra should inform their health care professionals of their intent to ingest garlic dietary supplements. Continuous subcutaneous infusion dosage.

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Hypoglycemia, sometimes resulting in coma, can occur. Only regular insulin, insulin lispro, insulin glulisine, and insulin aspart should be used for continuous subcutaneous insulin infusion CSII administration in external pumps. Moderate In patients taking insulin or other antidiabetic agents, the signs and pacmage of acute metyrapone toxicity e. In each case, it may be necessary to adjust your insulin dose to avoid blood sugar levels that are either too low or too high.

Twice daily insulin regimens consist of 2 subcutaneous insulin injections given per day; approximately two-thirds of the total daily insulin dose is given in the morning and one-third in the evening. Monitor patients for increase in triglyceride concentrations. Because of this, a potential pharmacodynamic interaction exists between these drugs and all antidiabetic agents.

Mixing of insulin glulisine for subcutaneous intermittent administration only: As for all insulins, injection sites and infusion sites within an-injection area abdomen, thigh or upper arm must be rotated from one injection to the next.

Moderate The concomitant use of clarithromycin and insulin or other antidiabetic agents can result in significant hypoglycemia.

Only use needles that are compatible for use with SoloStar.